Role of intercellular adhesion molecule-2 in osteoclastogenesis

Intercellular adhesion molecule-1 clusters during osteoclastogenesis.

Adhesion between osteoblasts and osteoclast precursors is established via an interaction involving intercellular adhesion molecule-1 (ICAM-1) on osteoblasts and leukocyte function-associated antigen-1 (LFA-1) on osteoclast precursors. The latter cells also express ICAM-1, but little is known about the expression over time and its possible role during osteoclastogenesis. In the present study we ...

Characterization of murine intercellular adhesion molecule-2.

Rat mAbs were raised against murine intercellular adhesion molecule-2 (ICAM-2). Immune precipitation and purification reveal that the murine ICAM-2 glycoprotein is 55 kDa and is similar in size to human ICAM-2. ICAM-2 is expressed on a variety of leukocyte cell lines, including T and B lymphoma, mastocytoma, and macrophage lines. ICAM-2 is well expressed on endothelioma cell lines, and in contr...

Soluble Intercellular Adhesion Molecule

Previous studies have suggested that intercellular ad¬ hesion molecule 1 (ICAM-1, CD54) may be involved in the pathogenesis ofasthma. In addition, a soluble form of ICAM-1 (sICAM-1) has been detected in increased concentrations in the sera of patients with certain in¬ flammatory conditions. To determine whether bron¬ chial asthma is associated with increased levels of sICAM-1 in serum and to as...

Intercellular Adhesion Molecule (ICAM)-1,

Intercellular Adhesion Molecule-1 Expression